2016-2020

“Development of Antibiotics that Dysregulate the Neisserial ClpP Protease.” Binepal, G; Mabanglo, M. F.; Goodreid, J. D.; Leung, E.; Bargash, M.; Wong, K.; Lin, F.; Cossette, M.; Bansagi, J.; Song, B.; Balasco Serrão, V. H.; Pai, E. F.; Batey, R.A.; Gray-Owen, S. D.; Houry, W. A. ACS Infectious Diseases 2020, 6, 3224-3236. (DOI: 10.1021/acsinfecdis.0c00599)

“Functional Characterization of a PROTAC Directed Against BRAF^V600E.” Posternak, G.; Tang, X.; Maisonneuve, P.; Jin, T.; Lavoie, H.; Daou, S.; Orlicky, S.; Goullet de Rugy, T.; Caldwell, L.; Chan, K.; Aman, A.; Prakesch, M.; Poda, G.; Mader, P.; Wong, C.; Maier, S.; Kitaygorodsky, J.; Larsen, B.; Colwill, K.; Ceccarelli, D. F.; Batey, R. A.; Taipale, M.; Kurinov, I.; Uehling, D.; Wrana, J.; Durocher, D.; Gingras, A.-C.; Al-Awar, R.; Therrien, M.; Sicheri, F. Nature Chem. Bio. 2020, 16, 1170-1178. (DOI:10.1038/s41589-020-0609-7)

“Di-tert-butyl Ethynylimidodicarbonate as a General Synthon for the β-Aminoethylation of Organic Electrophiles: Application to the Formal Synthesis of Pyrrolidinoindoline Alkaloids (±)-CPC-1 and (±)-Alline.” Beveridge, R. E.; Hu, Y.; Gregoire, B.; Batey, R. A. J. Org. Chem. 2020, 85, 8447–8461. (DOI: 10.1021/acs.joc.0c00781)

*“*Stereocontrolled Microwave-Assisted Domino [3,3]-Sigmatropic Reactions: A Winstein-Overman Rearrangement for the Formation of Differentiated Contiguous C–N Bonds.” Tjeng, A. A.; Handore, K. L.; Batey, R. A. Org. Lett. 2020, 22, 3050–3055. (DOI: 10.1021/acs.orglett.0c00801)

“Development of Small Molecules to Modulate the Activity of the ATP-Dependent ClpP Protease as a Novel Antibacterial and Anticancer Drug Target.” Lin, F.; Mabanglo, M. F.; Houry, W. A.; Batey, R. A. Med. Chem. Rev. 2019, 54, 379–404. (Review) (DOI: 10.29200/acsmedchemrev-v54.ch18)

“ClpP Protease Activation Results from the Reorganization of the Electrostatic Interaction Networks at the Entrance Pores.” Mabanglo, M. F.; Leung, E.; Vahidi, S.; Seraphim, T. V.; Eger, B. Y.; Bryson, S.; Bhandari, V.; Zhou, J. L.; Mao, Y.-Q.; Rizzolo, K.; Barghash, M. M.; Goodreid, J. D.; Phanse, S.; Babu, M.; Barbosa, L. R. S.; Ramos, C. H. I.; Batey, R. A.; Kay, L. E.; Pai, E. F.; Houry, W. A. *Commun. Biol*. 2019, 2, 410. (DOI: 10.1038/s42003-019-0656-3)

"An Approach to the 9-Oxo-10-oxabicyclo[5.3.0]dec-2-ene Core Structure of the Guaianolide and Pseudoguaianolide Sesquiterpenes via Domino Electrocyclic Ring Opening / Carboxylic Acid Trapping of a Dibromocyclopropane." Kim, S. J.; Lough, A. J.; Batey, R. A. J. Org. Chem. 2018, 83, 13799–13810. (DOI: 10.1021/acs.joc.8b02081)

“Lanthanide(III)-catalyzed Synthesis of trans-Diaminocyclopentenones from Substituted Furfurals and Secondary Amines via a Domino Ring-opening / 4pi-Electrocyclization Pathway.” Hiscox, A.; Ribeiro, K.; Batey, R. A. Org. Lett. 2018, 20, 6668–6672. (DOI: 10.1021/acs.orglett.8b02711)

“Enantioselective Isoquinuclidine Synthesis via Sequential Diels-Alder / Visible-Light Photoredox C–C Bond Cleavage: A Formal Synthesis of the Indole Alkaloid Catharanthine.” Kim, S. J.; Batey, R. A. Org. Chem. Frontiers 2018, 5, 2934–2939. (DOI: doi.org/10.1039/C8QO00849C)

“Total Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization to Avoid a Competing Thorpe-Ingold Effect Accelerated Transesterification.” Chojnacka, M. W.; Batey, R. A. Org. Lett. 2018, 20, 5671–5675. (DOI: doi.org/10.1021/acs.orglett.8b02396)

“Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death." Wong, K. S.; Mabanglo, M. F.; Seraphim, T. V.; Mollica, A.; Mao, Y.-Q.; Rizzolo, K.; Leung, E.; Moutaoufik, M. T.; Hoell, L.; Phanse, S.; Goodreid, J.; Barbosa, L. R. S.; Ramos, C. H. I.; Babu, M.; Mennella, V.; Batey, R. A.; Schimmer, A. D.; Houry, W. A. Cell Chem. Bio., 2018, 25, 1017–1030.e9. (DOI: doi.org/10.1016/j.chembiol.2018.05.014)

"The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases." Bhandari, V.; Wong, K. S.; Zhou, J. L.; Mabanglo, M. F.; Batey, R. A.; Houry, W. A. ACS Chem. Bio., 2018, 13, 1413–1425. (DOI: 10.1021/acschembio.8b00124)

“An Alumino‐Mannich Reaction of Organoaluminum Reagents, Silylated Amines, and Aldehydes.” Tarasewicz, A.; Ensan, D.; Batey, R. A. Chem. Eur. J., 2018, 24, 6071-6074. (DOI: 10.1002/chem.201801012).

“Sequential O-Arylation / Lanthanide(III)-Catalyzed [3,3]-Sigmatropic Rearrangement of Bromo-Substituted Allylic Alcohols.”Ramadhar, T. R.; Kawakami, J.; Batey, R. A. Synlett, 2017, 28, 2865-2870. (DOI: 10.1055/s-0036-1590890).

"DABO Boronate Promoted Conjugate Allylation of a,b-Unsaturated Aldehydes Using Copper(II) Catalysis." Roest, P. C.; Michel, N. W. M.; Batey, R. A. J. Org. Chem., 2016, 81, 6774-6778. (DOI: 10.1021/acs.joc.6b00782)

“N-[(Dimethylamino) [(2-oxo-1(2H)-pyridinyl)oxy]methylene]-N-methylmethanaminium tetrafluoroborate.” Goodreid, J. D.; Batey, R. A. In e-EROS (electronic-Encyclopedia of Reagents for Organic Synthesis), 2016. (DOI: 10.1002/047084289X.rn01939)

“Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.” Goodreid, J. D.; Janetzko, J.; Santa Maria Jr., J. P.; Wong, K. S.; Leung, E.; Eger, B. T.; Bryson, S.; Pai, E. F.; Gray-Owen, S. D.; Walker, S.; Houry, W. A.; Batey, R. A. J. Med. Chem. 2016, 59, 624-646. (DOI: 10.1021/acs.jmedchem.5b01451)