2000-2010

Mao X, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, MacLean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011;117(6):1986-97. https://doi.org/10.1182/blood-2010-05-284810. Epub 2010.

Nowrouzi F, Janetzko J, Batey RA. Indium-promoted chemo- and diastereoselective allylation of α,β-epoxy ketones with potassium allyltrifluoroborate. Org Lett. 2010;12(23):5490-3. https://doi.org/10.1021/ol1023757. Epub 2010.

Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, Schimmer AD. The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood. 2010;116(18):3593-603. https://doi.org/10.1182/blood-2010-01-262675. Epub 2010.

Ramadhar TR, Kawakami J, Lough AJ, Batey RA. Stereocontrolled synthesis of contiguous C(sp3)-C(aryl) bonds by lanthanide(III)-catalyzed domino aryl-Claisen [3,3]-sigmatropic rearrangements. Org Lett. 2010;12(20):4446-9. https://doi.org/10.1021/ol1018147

Li X, Wood TE, Sprangers R, Jansen G, Franke NE, Mao X, Wang X, Zhang Y, Verbrugge SE, Adomat H, Li ZH, Trudel S, Chen C, Religa TL, Jamal N, Messner H, Cloos J, Rose DR, Navon A, Guns E, Batey RA, Kay LE, Schimmer AD. Effect of noncompetitive proteasome inhibition on bortezomib resistance. J Natl Cancer Inst. 2010;102(14):1069-82. https://doi.org/10.1093/jnci/djq198. Epub 2010.

Smith CD, Rosocha G, Mui L, Batey RA. Investigation of substituent effects on the selectivity of 4pi-electrocyclization of 1,3-diarylallylic cations for the formation of highly substituted indenes. J Org Chem. 2010;75(14):4716-27. https://doi.org/10.1021/jo100275q

Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010;115(11):2251-9. https://doi.org/10.1182/blood-2009-07-231191. Epub 2010.

Smith CD, Gavrilyuk JI, Lough AJ, Batey RA. Lewis Acid catalyzed three- component hetero-Diels-alder (povarov) reaction of N-arylimines with strained norbornene-derived dienophiles. J Org Chem. 2010;75(3):702-15. https://doi.org/10.1021/jo9021106

Rodrigues A, Lee EE, Batey RA. Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of 2-allyloxypyridines and related heterocycles. Org Lett. 2010;12(2):260-3. https://doi.org/10.1021/ol9025759

Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD, Batey RA, Schimmer AD. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010;9(1):246-56. https://doi.org/10.1158/1535-7163.MCT-09-0495. Epub 2010.

Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Schimmer AD. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009;114(14):3064-73. https://doi.org/10.1182/blood-2009-03-209965. Epub 2009. Erratum in: Blood. 2010;115(19):4006. Dick, John [corrected to Dick, John E].

Joyce LL, Batey RA. Heterocycle formation via palladium-catalyzed intramolecular oxidative C-H bond functionalization: an efficient strategy for the synthesis of 2-aminobenzothiazoles. Org Lett. 2009;11(13):2792-5. https://doi.org/10.1021/ol900958z

Nowrouzi F, Thadani AN, Batey RA. Allylation and crotylation of ketones and aldehydes using potassium organotrifluoroborate salts under Lewis acid and montmorillonite K10 catalyzed conditions. Org Lett. 2009;11(12):2631-4. https://doi.org/10.1021/ol900599q

Mao X, Li X, Sprangers R, Wang X, Venugopal A, Wood T, Zhang Y, Kuntz DA, Coe E, Trudel S, Rose D, Batey RA, Kay LE, Schimmer AD. Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma. Leukemia. 2009;23(3):585-90. https://doi.org/10.1038/leu.2008.232. Epub 2008.

Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther. 2008;7(11):3546-55. https://doi.org/10.1158/1535-7163.MCT-08-0569

Hurren R, Beheshti Zavareh R, Dalili S, Wood T, Rose D, Chang H, Jamal N, Messner H, Batey RA, Schimmer AD. A novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death. Apoptosis. 2008;13(6):748-55. https://doi.org/10.1007/s10495-008-0209-6

Viirre RD, Evindar G, Batey RA. Copper-catalyzed domino annulation approaches to the synthesis of benzoxazoles under microwave-accelerated and conventional thermal conditions. J Org Chem. 2008;73(9):3452-9. https://doi.org/10.1021/jo702145d. Epub 2008.

Bolshan Y, Batey RA. Enamide synthesis by copper-catalyzed cross-coupling of amides and potassium alkenyltrifluoroborate salts. Angew Chem Int Ed Engl. 2008;47(11):2109-12. https://doi.org/10.1002/anie.200704711

Li SW, Batey RA. Mild lanthanide(III) catalyzed formation of 4,5-diaminocyclopent-2-enones from 2-furaldehyde and secondary amines: a domino condensation/ring-opening/electrocyclization process. Chem Commun (Camb). 2007;(36):3759-61. https://doi.org/10.1039/b709337n. Epub 2007.

Gavrilyuk JI, Evindar G, Chen JY, Batey RA. Peptide-heterocycle hybrid molecules: solid-phase-supported synthesis of substituted N-terminal 5-aminotetrazole peptides via electrocyclization of peptidic imidoylazides. J Comb Chem. 2007;9(4):644-51. https://doi.org/10.1021/cc060119p. Epub 2007.

Evindar G, Batey RA. Parallel synthesis of a library of benzoxazoles and benzothiazoles using ligand-accelerated copper-catalyzed cyclizations of ortho- halobenzanilides. J Org Chem. 2006;71(5):1802-8. https://doi.org/10.1021/jo051927q

Gavrilyuk JI, Evindar G, Batey RA. Peptide-heterocycle hybrid molecules: solid-phase synthesis of a 400-member library of N-terminal 2-iminohydantoin peptides. J Comb Chem. 2006;8(2):237-46. https://doi.org/10.1021/cc050090+

Schimmer AD, Dalili S, Batey RA, Riedl SJ. Targeting XIAP for the treatment of malignancy. Cell Death Differ. 2006;13(2):179-88. https://doi.org/10.1038/sj.cdd.4401826

Lee EE, Batey RA. Palladium-catalyzed allylic transposition of (allyloxy) iminodiazaphospholidines: a formal [3,3]-aza-phospha-oxa-Cope sigmatropic rearrangement for the stereoselective synthesis of allylic amines. J Am Chem Soc. 2005;127(42):14887-93. https://doi.org/10.1021/ja054161k

Bolshan Y, Batey RA. A room-temperature protocol for the rhodium(I)-catalyzed addition of arylboron compounds to sulfinimines. Org Lett. 2005;7(8):1481-4. https://doi.org/10.1021/ol050014f

Twin H, Batey RA. Intramolecular hetero Diels-Alder (Povarov) approach to the synthesis of the alkaloids luotonin A and camptothecin. Org Lett. 2004;6(26):4913-6. https://doi.org/10.1021/ol0479848

Grzyb JA, Lough AJ, Batey RA. 1H-Imidazol-1-yl 1,2,3,4-tetrahydroisoquinolin-2-yl ketone. Acta Crystallogr C. 2004;60(Pt 10):o730-2. https://doi.org/10.1107/S0108270104019195. Epub 2004.

Li SW, Batey RA. Allylation and highly diastereoselective syn or anti crotylation of N-toluenesulfonylimines using potassium allyl- and crotyltrifluoroborates. Chem Commun (Camb). 2004;(12):1382-3. https://doi.org/10.1039/b403759f. Epub 2004.

Lee EE, Batey RA. Palladium-catalyzed [3,3] sigmatropic rearrangement of (allyloxy)iminodiazaphospholidines: allylic transposition of C--O and C--N functionality. Angew Chem Int Ed Engl. 2004;43(14):1865-8. https://doi.org/10.1002/anie.200353284

Tan C, Wei L, Ottensmeyer FP, Goldfine I, Maddux BA, Yip CC, Batey RA, Kotra LP. Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor. Bioorg Med Chem Lett. 2004;14(6):1407-10. https://doi.org/10.1016/j.bmcl.2004.01.064

Miller CA, Batey RA. Hetero Diels-Alder reactions of nitrosoamidines: an efficient method for the synthesis of functionalized guanidines. Org Lett. 2004;6(5):699-702. https://doi.org/10.1021/ol0363117

Joyce LL, Evindar G, Batey RA. Copper- and palladium-catalyzed intramolecular C-S bond formation: a convenient synthesis of 2-aminobenzothiazoles. Chem Commun (Camb). 2004;(4):446-7. https://doi.org/10.1039/b311591g. Epub 2004.

Quach TD, Batey RA. Ligand- and base-free copper(II)-catalyzed C-N bond formation: cross-coupling reactions of organoboron compounds with aliphatic amines and anilines. Org Lett. 2003;5(23):4397-400. https://doi.org/10.1021/ol035681s

Quach TD, Batey RA. Copper(II)-catalyzed ether synthesis from aliphatic alcohols and potassium organotrifluoroborate salts. Org Lett. 2003;5(8):1381-4. https://doi.org/10.1021/ol034454n

Evindar G, Batey RA. Peptide heterocycle conjugates: a diverted edman degradation protocol for the synthesis of N-terminal 2-iminohydantoins. Org Lett. 2003;5(8):1201-4. https://doi.org/10.1021/ol034032d

Powell DA, Ramsden PD, Batey RA. Phase-transfer-catalyzed alkylation of guanidines by alkyl halides under biphasic conditions: a convenient protocol for the synthesis of highly functionalized guanidines. J Org Chem. 2003;68(6):2300-9. https://doi.org/10.1021/jo0265535

Evindar G, Batey RA. Copper- and palladium-catalyzed intramolecular aryl guanidinylation: an efficient method for the synthesis of 2-aminobenzimidazoles. Org Lett. 2003;5(2):133-6. https://doi.org/10.1021/ol027061h

Thadani AN, Batey RA. A mild protocol for allylation and highly diastereoselective syn or anti crotylation of aldehydes in biphasic and aqueous media utilizing potassium allyl- and crotyltrifluoroborates. Org Lett. 2002;4(22):3827-30. https://doi.org/10.1021/ol026619i

Powell DA, Batey RA. Total synthesis of the alkaloids martinelline and martinellic acid via a hetero Diels-Alder multicomponent coupling reaction. Org Lett. 2002;4(17):2913-6. https://doi.org/10.1021/ol026293d

Batey RA, Shen M, Lough AJ. Carbamoyl-substituted N-heterocyclic carbene complexes of palladium(II): application to Sonogashira cross-coupling reactions. Org Lett. 2002;4(9):1411-4. https://doi.org/10.1021/ol017245g

Batey RA, Shen M, Santhakumar V, Yoshina-Ishii C. Parallel synthesis of tri- and tetrasubstituted ureas from carbamoyl imidazolium salts. Comb Chem High Throughput Screen. 2002;5(3):219-32. https://doi.org/10.2174/1386207024607211

Batey RA, Powell DA. Multi-component coupling reactions: synthesis of a guanidine containing analog of the hexahydropyrrolo[3,2-c]quinoline alkaloid martinelline. Chem Commun (Camb). 2001;(22):2362-3. https://doi.org/10.1039/b107431h

Batey RA, Powell DA. A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification. Org Lett. 2000;2(20):3237-40. https://doi.org/10.1021/ol006465b